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Genistein has two-way regulation of estrogen levels in the body and selectively binds to estrogen receptors. The clinical pharmacological application research mainly includes:

1. Genistein and cardiovascular disease

Genistein plays an important role in reducing the incidence of cardiovascular disease. Low-density lipoprotein cholesterol in the blood is high, which is easily oxidized and can cause atherosclerosis. The antioxidant effect can reduce cholesterol, inhibit the oxidation of low-density lipoprotein cholesterol (LDL), keep the LDL level in the blood at a low level, improve the abnormal state of peroxidation in the body caused by high fat, and relieve the peroxidative damage to the body. Genistein can up-regulate LDL receptors and increase LDL receptor activity, thereby promoting cholesterol clearance. Genistein also has the effect of inhibiting the proliferation of smooth muscle cells and angiogenesis and inhibiting cell adhesion, thereby reducing the incidence of cardiovascular disease.

2.Genistein and Cancer

Genistein has inhibitory and therapeutic effects on various cancers through ①antioxidant effect ②inhibition of tyrosine kinase activity ③inhibition of topoisomerase activity ④estrogen and anti-estrogen-like effect ⑤reduce tumor angiogenesis.

3. Genistein and climacteric syndrome in women

Genistein has weak estrogenic activity and has estrogenic effects. Studies have shown that women's menopause, due to ovarian degeneration, the reduction of estrogen in the body, there will be menopausal syndrome, and the intake of quantitative genistein during menopause can supplement the lack of estrogen in the body, and play a role in preventing and reducing women's menopausal syndrome. Experiments suggest that estrogen-like effect may be the main mechanism of genistein to prevent osteoporosis.