What are the biological activities of Hericium polysaccharides?

As a natural polymer compound, Hericium polysaccharide has various biological activities such as maintaining gastrointestinal health, anti-cancer, antioxidant, protecting nerves, lowering blood sugar and blood lipids, etc., and has broad market application prospects.

1. Maintain gastrointestinal health.

The polysaccharide extracted from the fruiting body of Hericium erinaceus can restore the levels of cytokines such as tumor necrosis factor-α(tumor necrosis factor-α,TNF-α), interleukin-10(interleukin-10, IL-10), interleukin-12(interleukin-12, IL-12), interleukin-17α(interleukin-17α,IL-17α) and interleukin-4(interleukin-4, IL-4 in the colon of rats induced by trinitrobenzene sulfonic acid to normal.

Reduce the expression of nuclear factor κB(nuclear factor kappa-B,NF-κB), TNF-α and IL-17α cytokines, enhance the survival rate of Bifidobacterium (Bifidobacterium), promote the growth of beneficial intestinal bacteria, and improve the intestinal immunity of rats.

2. Anti-cancer.

Hericium polysaccharide can regulate immunity by participating in the body's cellular immune response, improve the body's immune activity, and exert anti-tumor effects.

Hericium polysaccharide can promote the secretion of interferon-γ (IFN-γ) and IL-2 in the serum of S180 tumor-bearing mice, improve the body's immunity, and exert anti-tumor effects; Secondly, Hericium polysaccharide can produce cytotoxicity and directly inhibit the proliferation of cancer cells to achieve anti-tumor effects.

3. Antioxidant.

Hericium polysaccharide can complex with metal ions and prevent the production of reactive oxygen species.

Hericium polysaccharide can chelate with ferrous ions to prevent the production of reactive oxygen species and have an antioxidant effect.

4. Protecting nerves.

Hericium polysaccharide can promote the recovery of sensory function after peripheral nerve injury, and its mechanism of action may be related to the activation of the AKT/p38-MAPK signaling pathway and the recovery of the blood-nerve barrier.