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Berberine has antibacterial effects on hemolytic streptococcus, staphylococcus aureus, gonococcus, and Freund, Shigella Shigella, and enhances leukocyte phagocytosis. Berberine hydrochloride has been widely used in the treatment of gastroenteritis, bacillary dysentery, etc., and also has certain curative effects on tuberculosis, scarlet fever, acute tonsillitis and respiratory tract infections.

Pharmacodynamics

It has a broad antibacterial spectrum and has bacteriostatic effect on a variety of Gram-positive and negative bacteria in vitro, especially against hemolytic streptococcus, Staphylococcus aureus, Vibrio cholerae, meningococcus, Shigella, typhoid bacillus, diphtheria bacillus, etc. . Bacteriostatic at low concentration, sterilization at high concentration. It also has a certain inhibitory effect on influenza virus, amoeba, leptospirosis, and certain skin fungi. In vitro experiments confirmed that berberine can enhance the phagocytic ability of leukocytes and hepatic reticuloendothelial system. Shigella, hemolytic streptococcus, and Staphylococcus aureus are easily resistant to this product. This product has no cross-resistance with penicillin and streptomycin.

pharmacokinetics

Poor oral absorption. After injection, it quickly enters into various organs and tissues, and the plasma concentration is maintained for a long time. The plasma concentration after intramuscular injection is lower than the minimum inhibitory concentration. The drug is widely distributed, mostly in the heart, bone, lung and liver. The retention time in the tissue is short, and only a trace amount remains after 24 hours. Most of the drugs are metabolized and cleared in the body, and they are excreted in their original form within 48 hours, accounting for less than 5% of the dose.

It is said that this product can reduce the number of fimbriae on the surface of the bacteria, so that the bacteria cannot attach to human cells, and play a therapeutic role. This product also has an effect on Helicobacter, and can relieve gastritis, gastric and duodenal ulcers.